liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Establishing glycaemic control with continuous subcutaneous insulin infusion in children and adolescents with type 1 diabetes: Experience of the PedPump Study in 17 countries
Show others and affiliations
2008 (English)In: Diabetologia, ISSN 0012-186X, Vol. 51, no 9, 1594-1601 p.Article in journal (Refereed) Published
Abstract [en]

Aims/hypothesis: To assess the use of paediatric continuous subcutaneous infusion (CSII) under real-life conditions by analysing data recorded for up to 90 days and relating them to outcome. Methods: Pump programming data from patients aged 0-18 years treated with CSII in 30 centres from 16 European countries and Israel were recorded during routine clinical visits. HbA 1c was measured centrally. Results: A total of 1,041 patients (age: 11.8±4.2 years, diabetes duration: 6.0±3.6 years, average CSII duration: 2.0±1.3 years, HbA1c: 8.0±1.3% [means±SD]) participated. Glycaemic control was better in preschool (n=142, 7.5±0.9%) and pre-adolescent (6-11 years, n=321, 7.7±1.0%) children than in adolescent patients (12-18 years, n=578, 8.3±1.4%). There was a significant negative correlation between HbA1c and daily bolus number, but not between HbA1c and total daily insulin dose. The use of <6.7 daily boluses was a significant predictor of an HbA1c level >7.5%. The incidence of severe hypoglycaemia and ketoacidosis was 6.63 and 6.26 events per 100 patient-years, respectively. Conclusions/ interpretation: This large paediatric survey of CSII shows that glycaemic targets can be frequently achieved, particularly in young children, and the incidence of acute complications is low. Adequate substitution of basal and prandial insulin is associated with a better HbA1c. © 2008 Springer-Verlag.

Place, publisher, year, edition, pages
2008. Vol. 51, no 9, 1594-1601 p.
Keyword [en]
Adolescents, children, diabetic, HbA1c, hypoglycaemia, insulin infusion systems, ketoacidosis, type 1 diabetes mellitus
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-43468DOI: 10.1007/s00125-008-1072-2Local ID: 73926OAI: diva2:264327
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-10

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Ludvigsson, Johnny
By organisation
Faculty of Health SciencesPediatrics Department of Paediatrics in Linköping
In the same journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 17 hits
ReferencesLink to record
Permanent link

Direct link