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RECK, a novel matrix metalloproteinase regulator
Department of Surgery The Forth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Department of Surgery The Forth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Division of Biomedicine School of Life Science, University of Skövde, Skövde,.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Oncology . Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Oncology UHL.
2008 (English)In: Histology and Histopathology, ISSN 0213-3911, Vol. 23, no 7-9, 1003-1010 p.Article in journal (Refereed) Published
Abstract [en]

Extracellular matrix (ECM) macromolecules are important for creating the cellular environments required during development and morphogenesis of tissues. Matrix metalloproteinases (MMPs) are a family of Zn-dependent endopeptidases that collectively are capable of cleaving virtually all ECM substrates, and play an important role in some physiological and pathological processes. MMP activity can be inhibited by some natural and artificial inhibitors. A newly found membrane-anchored regulator of MMPs, the reversion-inducing-cysteine-rich protein with kazal motifs (RECK), is downregulated when the cells undergo a process of malignant transformation, and is currently the subject of considerable research activity because of its specific structure and function. In this review, we have chosen to concentrate our efforts on the structure, function, regulation, and future prospect of RECK in order to provide a new target for prevention and treatment of tumours.

Place, publisher, year, edition, pages
2008. Vol. 23, no 7-9, 1003-1010 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-43640Local ID: 74465OAI: diva2:264500
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-10

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Sun, Xiao-Feng
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Faculty of Health SciencesOncology Department of Oncology UHL
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