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Clinicopathological significance of caspase-8 and caspase-10 expression in rectal cancer
Department of General Surgery West China Hospital, Sichuan University, Chengdu, China.
Department of General Surgery West China Hospital, Sichuan University, Chengdu, China.
Department of General Surgery West China Hospital, Sichuan University, Chengdu, China.
Department of General Surgery West China Hospital, Sichuan University, Chengdu, China.
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2008 (English)In: Oncology, ISSN 0890-9091, Vol. 74, no 3-4, 229-236 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: To investigate the expression of caspase-8 and -10 in rectal adenoma, adenocarcinoma and the corresponding normal mucosa tissue, and to clarify the relationship between their expression and clinicopathological parameters of rectal cancer. Methods: The expression of caspase-8 and -10 was determined by real-time RT-PCR and immunohistochemistry in 36 rectal adenomas, 93 rectal cancers and 93 corresponding normal rectal mucosa samples. Results: Compared with normal mucosa, the mRNA expression of caspase-8 was higher in adenomas (p = 0.003), while that of caspase-10 was lower in adenomas (p = 0.035) and cancers (p = 0.001). Immunohistochemical results showed caspase-8 up-regulation in adenomas (p = 0.014), and caspase-10 down-regulation in adenomas (p = 0.034) and cancers (p < 0.001) compared with normal mucosa samples. Cancers with poor differentiation had lower caspase-10 mRNA and protein levels than those with better differentiation (p = 0.041 and p = 0.046, respectively). The protein expression of caspase-8 and -10 was in accordance with the mRNA expression (p = 0.043 and p = 0.018, respectively). Conclusions: Caspase-8 expression was up-regulated in rectal adenomas. Caspase-10 expression was down-regulated in both rectal adenomas and cancers, and was further related to differentiation. Caspase-8 and -10 may be involved in the pathogenesis of rectal cancer. Copyright © 2008 S. Karger AG.

Place, publisher, year, edition, pages
2008. Vol. 74, no 3-4, 229-236 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-43644DOI: 10.1159/000151392Local ID: 74470OAI: oai:DiVA.org:liu-43644DiVA: diva2:264504
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-10

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Sun, Xiao-Feng

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