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PEG-stabilized carbodiimide crosslinked collagen-chitosan hydrogels for corneal tissue engineering
Department of Chemical Engineering University of Ottawa, Ottawa, Ontario K1N 6N5, Canada.ORCID iD: 0000-0001-6024-4144
University of Ottawa Eye Institute, Ottawa, Ontario K1H 8L6, Canada.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Ophthalmology. Östergötlands Läns Landsting, Reconstruction Centre, Department of Ophthalmology UHL.
University of Ottawa Eye Institute, Ottawa, Ontario K1H 8L6, Canada.
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2008 (English)In: Biomaterials, ISSN 0142-9612, E-ISSN 1878-5905, Vol. 29, no 29, 3960-3972 p.Article in journal (Refereed) Published
Abstract [en]

Implantable biomaterials that mimic the extracellular matrix (ECM) in key physical and physiological functions require components and microarchitectures that are carefully designed to maintain the correct balance between biofunctional and physical properties. Our goal was to develop hybrid polymer networks (HPN) that combine the bioactive features of natural materials and physical characteristics of synthetic ones to achieve synergy between the desirable mechanical properties of some components with the biological compatibility and physiological relevance of others. In this study, we developed collagen-chitosan composite hydrogels as corneal implants stabilized by either a simple carbodiimide cross-linker or a hybrid cross-linking system comprised of a long-range bi-functional cross-linker (e.g. poly(ethylene glycol) dibutyraldehyde (PEG-DBA)), and short-range amide-type cross-linkers (e.g. 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC), and N-hydroxysuccinimide (NHS)). Optimum hybrid hydrogel demonstrated significantly enhanced mechanical strength and elasticity by 100 and 20%, respectively, compared to its non-hybrid counterpart. It demonstrated excellent optical properties, optimum mechanical properties and suturability, and good permeability to glucose and albumin. It had excellent biocompatibility and when implanted into pig corneas for 12 months, allowed seamless host-graft integration with successful regeneration of host corneal epithelium, stroma, and nerves. © 2008 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
2008. Vol. 29, no 29, 3960-3972 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-43657DOI: 10.1016/j.biomaterials.2008.06.017Local ID: 74490OAI: diva2:264517
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2014-10-08

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Rafat, MehrdadFagerholm, PerLagali, Neil S.Griffith, May
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Faculty of Health SciencesOphthalmologyDepartment of Ophthalmology UHL
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