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Improving the sensitivity of a quartz crystal microbalance for biosensing by using porous gold
Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Biotechnology .
2001 (English)Article in journal (Refereed) Published
Abstract [en]

A quartz crystal microbalance can be used as a biosensor if biological receptor molecules (ligands) are attached to the crystal. To improve the sensitivity, the surface area of the gold electrodes on the crystal was increased by rendering the electrodes porous. This increased the response up to a factor of 3. A protein model system with human anti-myoglobin as ligand and sheep skeletal myoglobin at different concentrations as analyte was used. The quartz crystal was mounted in a flow-cell, where immobilisation, binding and regeneration of the surface were carried out. The kinetics of the model system was monitored under various experimental conditions.

Place, publisher, year, edition, pages
2001. Vol. 136, no 1-2, 49-53 p.
National Category
Natural Sciences
URN: urn:nbn:se:liu:diva-43744DOI: 10.1007/s006040170066Local ID: 74651OAI: diva2:264604
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-13

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Mandenius, Carl-Fredrik
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The Institute of TechnologyBiotechnology
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ReferencesLink to record
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