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Assessment of tissue viability by polarization spectroscopy
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Dermatology and Venerology. Östergötlands Läns Landsting, Centre for Medicine, Department of Dermatology and Venerology in Östergötland.
Linköping University, Department of Clinical and Experimental Medicine, Surgery. Linköping University, Faculty of Health Sciences.
Department of Physics University of Limeric, Ireland.
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2008 (English)In: Opto-Electronics Review, ISSN 1230-3402, E-ISSN 1896-3757, Vol. 16, no 3, 309-313 p.Article in journal (Refereed) Published
Abstract [en]

A new and versatile method for tissue viability imaging based on polarization spectroscopy of blood in superficial tissue structures such as the skin is presented in this paper. Linearly polarized light in the visible wavelength region is partly reflected directly by the skin surface and partly diffusely backscattered from the dermal tissue matrix. Most of the directly reflected light preserves its polarization state while the light returning from the deeper tissue layers is depolarized. By the use of a polarization filter positioned in front of a sensitive CCD-array, the light directly reflected from the tissue surface is blocked, while the depolarized light returning from the deeper tissue layers reaches the detector array. By separating the colour planes of the detected image, spectroscopic information about the amount of red blood cells (RBCs) in the microvascular network of the tissue under investigation can be derived. A theory that utilizes the differences in light absorption of RBCs and bloodless tissue in the red and green wavelength region forms the basis of an algorithm for displaying a colour coded map of the RBC distribution in a tissue. Using a fluid model, a linear relationship (cc. = 0.99) between RBC concentration and the output signal was demonstrated within the physiological range 0–4%. In-vivo evaluation using transepidermal application of acetylcholine by the way of iontophoresis displayed the heterogeneity pattern of the vasodilatation produced by the vasoactive agent. Applications of this novel technology are likely to be found in drug and skin care product development as well as in the assessment of skin irritation and tissue repair processes and even ultimately in a clinic case situation.

Place, publisher, year, edition, pages
SpringerLink , 2008. Vol. 16, no 3, 309-313 p.
Keyword [en]
tissue viability imaging, red blood cells, polarization spectroscopy, vasodilatation, vasoconstriction
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-44251DOI: 10.2478/s11772-008-0019-yLocal ID: 76117OAI: diva2:265113
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2013-10-21Bibliographically approved

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Nilsson, GertAnderson, ChrisHenricson, JoakimSjöberg, Folke
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Biomedical InstrumentationThe Institute of TechnologyFaculty of Health SciencesDermatology and VenerologyDepartment of Dermatology and Venerology in ÖstergötlandSurgeryBurn CenterDepartment of Plastic Surgery, Hand surgery UHL
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Opto-Electronics Review
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