liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Amount of maternal rotavirus-specific antibodies influence the outcome of rotavirus vaccination of newborn mice with virus-like particles
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine.
Show others and affiliations
2008 (English)In: Vaccine, ISSN 0264-410X, Vol. 26, no 6, 778-785 p.Article in journal (Refereed) Published
Abstract [en]

In presence of low or high levels of rotavirus-specific maternal antibodies, the ability of newborn mice to respond to immunization with rotavirus RF 8*-2/6/7 VLPs, was evaluated. After parenteral vaccination, 100% of offspring born to low-antibody-titer dams developed rotavirus-specific IgG antibodies (n = 7). In contrast, only 25% of offsprings born to high-antibody-titer dams responded to parenteral immunization (n = 12). When comparing parenteral versus oral immunization in offspring to low-antibody-titer dams only 45% responded after oral immunization (n = 6). In conclusion, the response to parenteral immunization was not hampered by the presence of low levels of maternal antibodies induced by a natural infection while oral immunization was impaired. However, high levels of maternal antibodies impaired the response to parenteral immunization. © 2008 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
2008. Vol. 26, no 6, 778-785 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-44282DOI: 10.1016/j.vaccine.2007.11.089Local ID: 76170OAI: diva2:265144
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-10

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Istrate, ClaudiaHinkula, JormaSvensson, Lennart
By organisation
Faculty of Health SciencesDepartment of Clinical and Experimental MedicineMolecular Virology
In the same journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 35 hits
ReferencesLink to record
Permanent link

Direct link