Amount of maternal rotavirus-specific antibodies influence the outcome of rotavirus vaccination of newborn mice with virus-like particles
2008 (English)In: Vaccine, ISSN 0264-410X, Vol. 26, no 6, 778-785 p.Article in journal (Refereed) Published
In presence of low or high levels of rotavirus-specific maternal antibodies, the ability of newborn mice to respond to immunization with rotavirus RF 8*-2/6/7 VLPs, was evaluated. After parenteral vaccination, 100% of offspring born to low-antibody-titer dams developed rotavirus-specific IgG antibodies (n = 7). In contrast, only 25% of offsprings born to high-antibody-titer dams responded to parenteral immunization (n = 12). When comparing parenteral versus oral immunization in offspring to low-antibody-titer dams only 45% responded after oral immunization (n = 6). In conclusion, the response to parenteral immunization was not hampered by the presence of low levels of maternal antibodies induced by a natural infection while oral immunization was impaired. However, high levels of maternal antibodies impaired the response to parenteral immunization. © 2008 Elsevier Ltd. All rights reserved.
Place, publisher, year, edition, pages
2008. Vol. 26, no 6, 778-785 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-44282DOI: 10.1016/j.vaccine.2007.11.089Local ID: 76170OAI: oai:DiVA.org:liu-44282DiVA: diva2:265144