Parenteral administration of RF 8-2/6/7 rotavirus-like particles in a one-dose regimen induce protective immunity in mice
2008 (English)In: Vaccine, ISSN 0264-410X, Vol. 26, no 35, 4594-4601 p.Article in journal (Refereed) Published
Rotavirus virus-like particles (RV-VLPs) represent a novel strategy for development of a rotavirus subunit vaccine. In this study, RF 8-2/6/7-VLPs with rotavirus VP8 protein (amino acid 1-241 of VP4) fused to the amino terminal end of a truncated VP2, were evaluated for their immunogenic and protective properties. A single intramuscular dose of, either 2 or 20 μg, RF 8-2/6/7-VLPs alone or combined with a potent adjuvant poly[di(carboxylatophenoxy)]phosphazene] (PCPP) induced rotavirus-specific serum IgG and IgA, fecal IgG titers that were enhanced 5-90-fold by adjuvant. Passive protective immunity was achieved in offspring to dams vaccinated with 2 and 20 μg RV-VLPs in presence of adjuvant and 20 μg RV-VLP without adjuvant. © 2008 Elsevier Ltd. All rights reserved.
Place, publisher, year, edition, pages
2008. Vol. 26, no 35, 4594-4601 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-44297DOI: 10.1016/j.vaccine.2008.05.089Local ID: 76191OAI: oai:DiVA.org:liu-44297DiVA: diva2:265159