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Parenteral administration of RF 8-2/6/7 rotavirus-like particles in a one-dose regimen induce protective immunity in mice
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Molecular Virology .
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2008 (English)In: Vaccine, ISSN 0264-410X, Vol. 26, no 35, 4594-4601 p.Article in journal (Refereed) Published
Abstract [en]

Rotavirus virus-like particles (RV-VLPs) represent a novel strategy for development of a rotavirus subunit vaccine. In this study, RF 8-2/6/7-VLPs with rotavirus VP8 protein (amino acid 1-241 of VP4) fused to the amino terminal end of a truncated VP2, were evaluated for their immunogenic and protective properties. A single intramuscular dose of, either 2 or 20 μg, RF 8-2/6/7-VLPs alone or combined with a potent adjuvant poly[di(carboxylatophenoxy)]phosphazene] (PCPP) induced rotavirus-specific serum IgG and IgA, fecal IgG titers that were enhanced 5-90-fold by adjuvant. Passive protective immunity was achieved in offspring to dams vaccinated with 2 and 20 μg RV-VLPs in presence of adjuvant and 20 μg RV-VLP without adjuvant. © 2008 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
2008. Vol. 26, no 35, 4594-4601 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-44297DOI: 10.1016/j.vaccine.2008.05.089Local ID: 76191OAI: oai:DiVA.org:liu-44297DiVA: diva2:265159
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-10

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Istrate, ClaudiaHinkula, JormaSvensson, Lennart

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