Neuroprotective Effect of Genistein in 6-Hydroxydopamine Hemi-parkinsonian Rat Model
2008 (English)In: Phytotherapy Research, ISSN 0951-418X, E-ISSN 1099-1573, Vol. 23, no 1, 132-135 p.Article in journal (Refereed) Published
A large body of experimental evidence supports a role for oxidative stress as a mediator of nerve cell death in Parkinson-s disease (PD). Phytoestrogens such as genistein have been reported to prevent neuronal degeneration caused by increased oxidative burden, therefore, this study examined whether genistein administration at a high dose would attenuate behavioral and structural abnormalities in an experimental model of PD in rat. For this purpose, unilateral intrastriatal 6-hydroxydopamine (6-OHDA, 12.5 μg/5 μL of saline-ascorbate)- lesioned rats were intraperitoneally pretreated with a single and high dose of genistein (10 mg/kg) 1 h before surgery. Apomorphine-induced rotations and the number of Nissl-stained neurons in the substantia nigra pars compacta (SNC) were counted after 2 weeks. Genistein administration could attenuate the rotational behavior in lesioned rats and protect the neurons of SNC against 6-OHDA toxicity. Genistein administration has a protective effect against 6-OHDA toxicity.
Place, publisher, year, edition, pages
2008. Vol. 23, no 1, 132-135 p.
genistein • Parkinson's disease • 6-hydroxydopamine • rotation • rat
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-44303DOI: 10.1002/ptr.2564PubMedID: 18693302Local ID: 76209OAI: oai:DiVA.org:liu-44303DiVA: diva2:265165