Increased plasma levels of asymmetric dimethylarginine in patients with carotid stenosis: No evidence for the role of the common FABP2 A54T gene polymorphism
2007 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, Vol. 115, no 2, 90-96 p.Article in journal (Refereed) Published
Objective - Both asymmetric dimethylarginine (ADMA), which is an inhibitor of endothelial nitric oxide synthase and the fatty acid-binding protein 2 (FABP2) A54T gene polymorphism have been associated with cerebrovascular disease. The objective of the present study was to investigate the role of ADMA and the FABP2 A54T polymorphism in carotid atherosclerosis. Material and methods - 54 patients with severe carotid stenosis and 54 matched controls without significant carotid stenosis were compared. ADMA was analysed with an ELISA method. The FABP2 A54T polymorphism was determined with a polymerase chain reaction-restriction fragment length polymorphism technique. Results - Patients with carotid stenosis had higher ADMA levels (0.76 ± 0.16 μmol/l) than the controls (0.70 ± 0.14 μmol/l, P < 0,01). Allele and genotype frequencies of the FABP2 polymorphism did not differ between patients and controls. Conclusions - ADMA levels in subjects with carotid stenosis are increased which emphasize the role of ADMA as a novel risk factor for atherosclerosis and future cardiovascular risk. The FABP2 A54T polymorphism is not associated with severe carotid stenosis. © 2007 The Authors.
Place, publisher, year, edition, pages
2007. Vol. 115, no 2, 90-96 p.
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-45402DOI: 10.1111/j.1600-0404.2006.00764.xLocal ID: 82631OAI: oai:DiVA.org:liu-45402DiVA: diva2:266264