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Neuromuscular block and the electroencephalogram during sevoflurane anaesthesia
KI Stockholm.
KI Stockholm.
KI Stockholm.
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2007 (English)In: NeuroReport, ISSN 0959-4965, Vol. 18, no 17, 1817-1820 p.Article in journal (Refereed) Published
Abstract [en]

The effect of neuromuscular block on the anaesthetic depth of hypnosis is an elusive question. We simultaneously investigated the influence of neuromuscular block on the bispectral index, a measure of hypnosis during general anaesthesia, and on the electroencephalogram. Patients were anaesthetized with sevoflurane. Noxious tetanic electrical stimulation was applied on two occasions: before and after profound neuromuscular block achieved with rocuronium. Neuromuscular block significantly attenuated the effect from noxious stimulation on electroencephalogram power and synchrony in the γ band (P<0.05), and the corresponding effect on bispectral index (P<0.02). These findings are probably due to the reduced arousing afferent input from paralysed muscles, and not to changes in the frontal electromyogram. © 2007 Lippincott Williams & Wilkins, Inc.

Place, publisher, year, edition, pages
2007. Vol. 18, no 17, 1817-1820 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-45405DOI: 10.1097/WNR.0b013e3282f13e11Local ID: 82634OAI: diva2:266267
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-11

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Brudin, Lars
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