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Guidelines for sampling, measuring and reporting ionized magnesium in undiluted serum, plasma or blood: International Federation of Clinical Chemistry and Laboratory Medicine (IFCC)
Ben Rayana, M.C., Laboratory of Clinical Chemistry, National Institute of Nutrition, Bab Saadoun, Tunis, Tunisia.
Department of Pathology, Hartford Hospital, Hartford, CT, United States.
Department of Chemistry, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom.
Instrumentation Laboratory, Lexington, MA, United States.
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2005 (English)In: Clinical Chemistry and Laboratory Medicine, ISSN 1434-6621, Vol. 43, no 5, 564-569 p.Article in journal (Refereed) Published
Abstract [en]

All analyzers with ion-selective electrodes for ionized magnesium (iMg) should yield comparable and unbiased results. The prerequisite to achieve this goal is to reach consensus on sampling, measurement and reporting. The recommended guidelines for sampling, measurement and reporting iMg in plasma ("plasma" refers to circulating plasma and the forms in which it is sampled: the plasma phase of anticoagulated whole blood, plasma separated from blood cells, or serum) or blood, referring to the substance concentration of iMg in the calibrants, will provide results for iMg that are approximately 3% greater than its true concentration, and 4% less than its true molality. Binding of magnesium to proteins and ligands in plasma and blood is pH-dependent. Therefore, pH should be simultaneously measured to allow adjustment of iMg concentration to pH 7.4. The substance concentration of iMg may be physiologically and consequently clinically more relevant than the substance concentration of total magnesium. © 2005 by Walter de Gruyter.

Place, publisher, year, edition, pages
2005. Vol. 43, no 5, 564-569 p.
Keyword [en]
Erythrocyte, Heparin, Influence factors, Interference, Ion-selective electrode, Ionized calcium, Ionized magnesium, Lipophilic anions, Liquid junction potential, pH, Protein, Sampling, Silicone, Sodium
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-45452DOI: 10.1515/CCLM.2005.098OAI: diva2:266348
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-12

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