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Quantitative T-wave analysis predicts 1 year prognosis and benefit from early invasive treatment in the FRISC II study population
Department of Medicine B, H:S Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100, Copenhagen, Denmark, Department of Medicine B, Hilleroed Hospital, DK-3400 Hilleroed, Denmark.
Duke Clinical Research Institute, Durham, NC, United States.
Department of Medicine B, H:S Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100, Copenhagen, Denmark.
Heart and Lung Center, Ulleval University Hospital, Oslo, Norway.
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2005 (English)In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 26, no 2, 112-118 p.Article in journal (Refereed) Published
Abstract [en]

Aims: To investigate the prognostic value of T-wave abnormalities in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS), and whether such ECG changes may predict benefit from an early coronary angiography. Although ST-segment changes are considered the most important ECG feature in NSTE-ACS, T-wave abnormalities are the most common ECG finding. We hypothesize that a new quantitative approach to T-wave analysis could improve the prognostic value of this ECG abnormality. Methods and results: Quantitative T-wave analysis was performed on the admission ECG in 1609 patients with NSTE-ACS. Nine different categories of T-wave abnormality were analysed for their prognostic value concerning clinical outcome in patients not randomized to early coronary angiography. Also, the presence of one category (i.e. T-wave abnormality in >6 leads) was analysed for its predictive value concerning benefit from early coronary angiography. The combined study endpoint was death or myocardial infarction at 1 year follow-up. Patients with >6 leads with abnormal T-waves and concomitant ST-segment depression had a higher risk when not receiving early coronary angiography (24 vs. 12%, respectively, P = 0.003), but could be brought to the same level of risk as the remaining patients with this treatment. For non-invasively treated patients five different categories of T-wave abnormality were significantly associated with an adverse outcome. Conclusion: New quantitative T-wave analysis of the admission ECG gives additional predictive information concerning clinical outcome and identifies patients who benefit from early coronary angiography.

Place, publisher, year, edition, pages
2005. Vol. 26, no 2, 112-118 p.
Keyword [en]
Acute coronary syndrome, Non-ST elevation myocardial infarction, Unstable angina pectoris
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-45537DOI: 10.1093/eurheartj/ehi026OAI: oai:DiVA.org:liu-45537DiVA: diva2:266433
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-13

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Swahn, Eva

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