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Galanin expression in a murine model of allergic contact dermatitis
Unit of Dermatology and Venereology, Karolinska University Hospital, Stockholm, Sweden, Unit of Dermatology and Venereology, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
Unit of Dermatology and Venereology, Karolinska University Hospital, Stockholm, Sweden.
U. of Occup. and Environ. Dermatol., Department of Medicine, Karolinska University Hospital, Stockholm, Sweden.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry. Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry.
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2004 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, Vol. 84, no 6, 428-432 p.Article in journal (Refereed) Published
Abstract [en]

Galanin is a neuropeptide widely distributed in the nervous system. The expression of galanin was investigated in murine contact allergy using immunohistochemistry, radioimmunoassay and in situ hybridization. Female BALB/c mice were sensitized with oxazolone and 6 days later challenged on the dorsal surface of ears, while control mice received vehicle. After 24 h, one ear was processed for immunostaining using a biotinylated fluorescence technique, while the other ear was frozen and processed for radioimmunoassay or in situ hybridization. Galanin immunoreactive nerve fibres were more numerous (p < 0.01) in the eczematous compared with control ears. Double-staining with antibody to the nerve fibre marker PGP (protein gene product) 9.5 revealed co-localization of PGP 9.5 and galanin in nerve fibres. Radioimmunoassay demonstrated a decrease (p < 0.04) in galanin concentration in eczematous compared with control ears. Our results suggest a role for galanin in murine contact allergy.

Place, publisher, year, edition, pages
2004. Vol. 84, no 6, 428-432 p.
Keyword [en]
Allergic contact dermatitis, Immunohistochemistry, Mouse, Neuropeptides, Radioimmunoassay, Sensory nerves
National Category
Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-45569DOI: 10.1080/00015550410017290OAI: oai:DiVA.org:liu-45569DiVA: diva2:266465
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-12

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Theodorsson, Elvar

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