liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The Dominant white, Dun and Smoky color variants in chicken are associated with insertion/deletion polymorphisms in the PMEL17 gene
Dept. Med. Biochem. and Microbiol., Uppsala University, SE-751 24 Uppsala, Sweden.
Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, United States.
Dept. Med. Biochem. and Microbiol., Uppsala University, SE-751 24 Uppsala, Sweden.
Dept. of Biochemistry and Biophysics, Stockholm University, SE-106 91 Stockholm, Sweden.
Show others and affiliations
2004 (English)In: Genetics, ISSN 0016-6731, E-ISSN 1943-2631, Vol. 168, no 3, 1507-1518 p.Article in journal (Refereed) Published
Abstract [en]

Dominant white, Dun, and Smoky are alleles at the Dominant white locus, which is one of the major loci affecting plumage color in the domestic chicken. Both Dominant white and Dun inhibit the expression of black eumelanin. Smoky arose in a White Leghorn homozygous for Dominant white and partially restores pigmentation. PMEL17 encodes a melanocyte-specific protein and was identified as a positional candidate gene due to its role in the development of eumelanosomes. Linkage analysis of PMEL17 and Dominant while using a red jungle fowl/White Leghorn intercross revealed no recombination between these loci. Sequence analysis showed that the Dominant white allele was exclusively associated with a 9-bp insertion in exon 10, leading to an insertion of three amino acids in the PMEL17 transmembrane region. Similarly, a deletion of five amino acids in the transmembrane region occurs in the protein encoded by Dun. The Smoky allele shared the 9-bp insertion in exon 10 with Dominant white, as expected from its origin, but also had a deletion of 12 nucleotides in exon 6, eliminating four amino acids from the mature protein. These mutations are, together with the recessive silver mutation in the mouse, the only PMEL17 mutations with phenotypic effects that have been described so far in any species.

Place, publisher, year, edition, pages
2004. Vol. 168, no 3, 1507-1518 p.
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-45597DOI: 10.1534/genetics.104.027995OAI: oai:DiVA.org:liu-45597DiVA: diva2:266493
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2010-06-28Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Authority records BETA

Jensen, Per

Search in DiVA

By author/editor
Jensen, Per
By organisation
Zoology
In the same journal
Genetics
Engineering and Technology

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 64 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf