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Neuromuscular blocking agents block carotid body neuronal nicotinic acetylcholine receptors
Dept. Anesth. Intensive Care Med., Karolinska Hospital and Institute, SE-171 76 Stockholm, Sweden.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care.
Dept. Anesth. Intensive Care Med., Karolinska Hospital and Institute, SE-171 76 Stockholm, Sweden.
Dept. of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.
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2004 (English)In: European Journal of Pharmacology, ISSN 0014-2999, Vol. 497, no 2, 173-180 p.Article in journal (Refereed) Published
Abstract [en]

Neuromuscular blocking agents predominantly block muscle type nicotinic acetylcholine receptors as opposed to the neuronal type. However, there is growing evidence that neuromuscular blocking agents have affinity to some neuronal nicotinic acetylcholine receptors. The carotid body chemoreceptor as the essential oxygen-sensing cell, relies on cholinergic signalling. Atracurium and vecuronium impair carotid body chemoreceptor activity during hypoxia. Here, we characterize atracurium and vecuronium as antagonists at nicotinic receptors of the carotid body chemoreceptor. Isolated rabbit carotid body preparations with carotid sinus nerve were used, and chemoreceptor activities were recorded. There was a concentration-dependent reduction in the chemoreceptor responses to nicotine, with an IC50 to 50 µg nicotine of 3.64 and 1.64 µM and to 500 µg nicotine of 27.00 µM and 7.29 µM for atracurium and vecuronium, respectively. It is concluded that atracurium and vecuronium depress nicotine-induced chemoreceptor responses of the carotid body in a dose-dependent fashion. © 2004 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
2004. Vol. 497, no 2, 173-180 p.
Keyword [en]
Acetylcholine receptor, Anesthetic, Atracurium, Carotid body, Nicotine, Vecuronium
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-45661DOI: 10.1016/j.ejphar.2004.06.052OAI: diva2:266557
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-12

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Wyon, Nicholas
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