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Histologic reactions to particulate wear debris in different mesenchymal tissues: Studies on the nonreplaced compartment from revised uni-knees
Department of Orthopaedics, Lund University Hospital, University of Lund, Lund, Sweden, Department of Orthopaedics, University Hospital, Getingevägen 4, S-221 85 Lund, Sweden.
Department of Biomedical Engineering, Institute of Orthopaedics, Royal National Orthopaedic Hospital, Stanmore, United Kingdom.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine .
2004 (English)In: The Journal of Arthroplasty, ISSN 0883-5403, Vol. 19, no 4, 481-487 p.Article in journal (Refereed) Published
Abstract [en]

The interface between bone and artificial-joint implants consists of soft tissue. This tissue varies from fibrocartilage to loose fibrous tissue. Tissues that resemble those can be found in normal joints. Sixteen knees with unicompartmental knee prostheses, revised because of excessive wear of the tibial insert, were studied. Synovium, synovial fluid, cartilage, and bone from the nonreplaced compartment were studied with light microscopy. We found wear particles and reactions to those in all tissues except cartilage. In the subchondral bone, we found osteolytic-like processes undermining the cartilage peripherally. Our conclusion from these findings is that the histologic composition of the bone-implant interface might be an important factor regarding the reaction of the tissue to wear particles and, thus, component fixation. © 2004 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
2004. Vol. 19, no 4, 481-487 p.
Keyword [en]
histology, joint prosthesis, retrieval, wear particles
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-45718DOI: 10.1016/j.arth.2003.11.013OAI: diva2:266614
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-12

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Ryd, Leif
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