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Relationship between the Incidence of Type 1 Diabetes and Enterovirus Infections in Different European Populations: Results from the EPIVIR Project
JDRF Center for Prevention of Type 1 Diabetes, Finland and Department of Virology, University of Tampere, Tampere, Finland.
Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
Department of Immunology, University of Tartu, Tartu, Estonia.
Department of Immunology, University of Tartu, Tartu, Estonia.
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2004 (English)In: Journal of Medical Virology, ISSN 0146-6615, E-ISSN 1096-9071, Vol. 72, no 4, 610-617 p.Article in journal (Refereed) Published
Abstract [en]

The incidence of type 1 diabetes varies markedly between countries. As enterovirus infections have been linked to type 1 diabetes, we determined whether this variation correlates with the frequency of enterovirus infections in different Caucasian populations in Europe. Enterovirus antibodies were examined in the background population (1-year-old and 10-14-year-old children) in seven countries with either exceptionally high (Finland and Sweden) or low/intermediate incidence of diabetes (Estonia, Germany, Hungary, Lithuania, Russia) using EIA and neutralisation assays. Enterovirus antibodies were less frequent in countries with high diabetes incidence compared to countries with low diabetes incidence (P < 0.001). This suggests that enterovirus infections are not particularly common in countries with high diabetes incidence. In contrast, there seems to be an inverse correlation between the incidence of type 1 diabetes and enterovirus infections in the background population, which is in line with the previously proposed polio hypothesis according to which the complications of enterovirus infections become more common in an environment with a decreased rate of infections. © 2004 Wiley-Liss, Inc.

Place, publisher, year, edition, pages
John Wiley & Sons, 2004. Vol. 72, no 4, 610-617 p.
Keyword [en]
Antibody, Enterovirus, Epidemiology, IgG, Type 1 diabetes
National Category
Infectious Medicine
URN: urn:nbn:se:liu:diva-45784DOI: 10.1002/jmv.20033ISI: 000220046100013OAI: diva2:266680
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2015-03-20Bibliographically approved

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Ludvigsson, Johnny
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PediatricsFaculty of Health SciencesDepartment of Paediatrics in Linköping
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