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Specific ion effects: Role of salt and buffer in protonation of cytochrome c
Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Theoretical Physics .
Research School of Physical Sciences and Engineering, Australian National University, Canberra 0200, Australia.
Research School of Physical Sciences and Engineering, Australian National University, Canberra 0200, Australia, Departments of Chemistry, Universities of Florence, Italy,.
2004 (English)In: The European Physical Journal E Soft matter, ISSN 1292-8941, E-ISSN 1292-895X, Vol. 13, no 3, 239-245 p.Article in journal (Refereed) Published
Abstract [en]

Changes in background salt and buffer are known to influence the properties of proteins. The reasons have remained obscure. The challenge posed by many such problems is this. Can physical chemistry contribute any predictive quantitative insights to what is in effect the simplest macromolecular solution behavior? Or must all remain specific? Our thesis is that it can. For definiteness we consider here as an illustrative example: surface pH and protonation equilibria of cytochrome c. We demonstrate an important role for ionic dispersion forces, missing from previous theoretical treatments. Unlike charge interactions these are different for each ionic species, and act between a protein and both salt and buffer ions. The charge of proteins depends not only on pH, ionic charge, and salt concentration. Taking ionic dispersion forces into account goes some way towards explaining the dependence on ionic species. We demonstrate why the addition of buffer can have profound effects, including reversal of the salt dependence of the protein charge. © EDP Sciences/ Società Italiana di Fisica/ Springer-Verlag 2004.

Place, publisher, year, edition, pages
2004. Vol. 13, no 3, 239-245 p.
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-45809DOI: 10.1140/epje/i2003-10072-0OAI: oai:DiVA.org:liu-45809DiVA: diva2:266705
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-13

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Boström, Mathias

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