liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Twelve years of fluconazole in clinical practice: Global-trends in species distribution and fluconazole susceptibility of bloodstream isolates of Candida
Department of Pathology, Roy J./Lucille A. Carver Coll. Med., University of Iowa, Iowa City, IA 52242, United States, Department of Medicine, Roy J./Lucille A. Carver Coll. Med., University of Iowa, Iowa City, IA 52242, United States, Department Epidemiology, Roy J./Lucille A. Carver Coll. Med., University of Iowa, Iowa City, IA 52242, United States, Medical Microbiology Division, Department of Pathology, Univ. of Iowa College of Medicine, Iowa City, IA 52242, United States.
Department of Pathology, Roy J./Lucille A. Carver Coll. Med., University of Iowa, Iowa City, IA 52242, United States, Department of Medicine, Roy J./Lucille A. Carver Coll. Med., University of Iowa, Iowa City, IA 52242, United States.
Christiana Care Health Services, Wilmington, DE, United States.
Clarion Health Methodist Hospital, Indianapolis, IN, United States.
Show others and affiliations
2004 (English)In: Clinical Microbiology and Infection, ISSN 1198-743X, E-ISSN 1469-0691, Vol. 10, no SUPPL. 1, 11-23 p.Article in journal (Refereed) Published
Abstract [en]

We determined the species distribution and in-vitro susceptibility of 6082 bloodstream infection (BSI) isolates of Candida spp. collected from 250 medical centres in 32 nations over a 10-year period from 1992 through 2001. The species included 3401 C. albicans, 984 C. glabrata, 796 C. parapsilosis, 585 C. tropicalis, 153 C. krusei, 67 C. lusitaniae, 48 C. guilliermondii, 10 C. famata, 10 C. kefyr, six C. pelliculosa, five C. rugosa, four C. lipolytica, three C. dubliniensis, three C. inconspicua, two C. sake and one isolate each of C. lambica, C. norvegensis and C. zeylanoides. Minimum inhibitory concentration determinations were made using the National Committee for Clinical Laboratory Standards reference broth microdilution method. Variation in the rank order and frequency of the different species of Candida was observed over time and by geographic area. The proportion of BSI due to C. albicans and C. glabrata increased and C. parapsilosis decreased over time in Canada, the USA and Europe. C. glabrata was an infrequent cause of BSI in Latin America and the Asia-Pacific region. Very little variation in fluconazole susceptibility was observed among isolates of C. albicans, C. tropicalis and C. parapsilosis. These species accounted for 78% of all BSI and remained highly susceptible (91-100% susceptible) to fluconazole from 1992 to 2001 irrespective of geographic origin. The prevalence of fluconazole resistance among C. glabrata isolates was variable both over time and among the various countries and regions. Resistance to fluconazole among C. glabrata isolates was greatest in the USA and varied by US census region (range 0-23%). These observations are generally encouraging relative to the sustained usefulness of fluconazole as a systemically active antifungal agent for the treatment of candida BSI. © 2004 Copyright by the European Society of Clinical Microbiology and Infectious Diseases.

Place, publisher, year, edition, pages
2004. Vol. 10, no SUPPL. 1, 11-23 p.
Keyword [en]
Candidemia, Fluconazole, Surveillance
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:liu:diva-45812DOI: 10.1111/j.1470-9465.2004.t01-1-00844.xOAI: oai:DiVA.org:liu-45812DiVA: diva2:266708
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-13

Open Access in DiVA

No full text

Other links

Publisher's full text
In the same journal
Clinical Microbiology and Infection
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 63 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf