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Overexpression of transferrin receptor and ferritin related to clinical symptoms and destabilization of human carotid plaques
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Health Sciences.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Experimental Pathology.
Burnett College of Biomedical Sciences, University of Central Florida, Orlando, FL 32816.
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2008 (English)In: Experimental biology and medicine (Maywood, N.J.: Print), ISSN 1535-3702, E-ISSN 1535-3699, Vol. 233, no 7, 818-826 p.Article in journal (Refereed) Published
Abstract [en]

Accumulation of tissue iron has been implicated in development of atherosclerotic lesions mainly because of increased iron-catalyzed oxidative injury. However, it remains unknown whether cellular iron import and storage in human atheroma are related to human atheroma development. We found that transferrin receptor 1 (TfR1), a major iron importer, is highly expressed in foamy macrophages and some smooth muscle cells in intimal lesions of human carotid atheroma, mainly in cytoplasmic accumulation patterns. In 52 human carotid atherosclerotic lesions, TfR1 expression was positively correlated with macrophage infiltration, ectopic lysosomal cathepsin L, and ferritin expression. Highly expressed TfR1 and ferritin in CD68-positive macrophages were significantly associated with development and severity of human carotid plaques, smoking, and patient's symptoms. The findings suggest that pathologic macrophage iron metabolism may contribute to vulnerability of human atheroma, established risk factors, and their clinical symptoms. The cytoplasmic overexpression of TfR1 may be the result of lysosomal dysfunction and ectopic accumulation of lysosomal cathepsin I caused by atheroma-relevant lipids in atherogenesis. Copyright © 2008 by the Society for Experimental Biology and Medicine.

Place, publisher, year, edition, pages
2008. Vol. 233, no 7, 818-826 p.
Keyword [en]
Apoptosis, Atherosclerosis, Iron metabolism, Lysosomes, Macrophages, Plaque rupture
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-45822DOI: 10.3181/0711-RM-320OAI: oai:DiVA.org:liu-45822DiVA: diva2:266718
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-13Bibliographically approved

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Li, WeiXu, LihuaYuan, Ximing

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Division of Cell BiologyFaculty of Health SciencesExperimental PathologyDepartment of Clinical and Experimental Medicine
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Medical and Health Sciences

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