Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory
2004 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, Vol. 101, no 5, 1368-1373 p.Article in journal (Refereed) Published
A conspicuous feature of cortical organization is the wide diversity of inhibitory interneurons, their differential computational functions remain unclear. Here we propose a local cortical circuit in which three major subtypes of interneurons play distinct roles. In a model designed for spatial working memory, stimulus tuning of persistent activity arises from the concerted action of widespread inhibition mediated by perisoma-targeting (parvalbumin-containing) interneurons and localized disinhibition of pyramidal cells via interneuron-targeting (calretinin-containing) interneurons. Moreover, resistance against distracting stimuli (a fundamental property of working memory) is dynamically controlled by dendrite-targeting (calbindin-containing) interneurons. The experimental observation of inverted tuning curves of monkey prefrontal neurons recorded during working memory supports a key model prediction. This work suggests a framework for understanding the division of labor and cooperation among different inhibitory cell types in a recurrent cortical circuit.
Place, publisher, year, edition, pages
2004. Vol. 101, no 5, 1368-1373 p.
Engineering and Technology
IdentifiersURN: urn:nbn:se:liu:diva-45823DOI: 10.1073/pnas.0305337101OAI: oai:DiVA.org:liu-45823DiVA: diva2:266719