Dendritic cells and toll-like receptors 2 and 4 in the ileum of Crohn's disease patients
2008 (English)In: Digestive Diseases and Sciences, ISSN 0163-2116, Vol. 53, no 7, 1917-1928 p.Article in journal (Refereed) Published
We investigated myeloid-dendritic cell (DC) marker and Toll-like receptor (TLR)-2 and 4 distributions in ileal samples from Crohn's disease (CD) patients (n = 14) and controls (n = 13). In controls, no TLR-2+ cells were observed, and higher numbers of TLR-4+ and DC-SIGN+ cells (P < 0.01) were detected in ileal samples when compared versus colonic tissues. In non-inflamed CD ileum, TLR-4+ and DC-SGN+ cells were depleted from superficial areas of the villus, and a significant CD1a+ cell infiltration (P < 0.01) was observed when compared to ileal controls and non-inflamed colonic CD samples. In inflamed CD ileum, DC-SIGN+, CD1a+, TLR-4+ and few TLR-4 +DC-SIGN+ cells were detected as well as CD83 depletion. No correlation between TLR-2 and DC markers was detected in CD samples. A unique distribution of myeloid-DC markers characterized the CD ileum. Also, the presence of significant amounts of ileal CD1a+ cells may provide a relevant DC-mediated mechanism for antigen recognition in the pathogenesis of CD. © 2007 Springer Science+Business Media, LLC.
Place, publisher, year, edition, pages
2008. Vol. 53, no 7, 1917-1928 p.
CD1a, Crohn's disease, Dendritic cells, Inflammation, Toll-like receptor
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-45878DOI: 10.1007/s10620-007-0105-xOAI: oai:DiVA.org:liu-45878DiVA: diva2:266774