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Dendritic cells and toll-like receptors 2 and 4 in the ileum of Crohn's disease patients
Department of Pathology and Molecular Medicine, McMaster University, Health Science Centre 3N5C, 1200 Main St. West, Hamilton, ON L8N 3Z5, Canada.
Internal Medicine Department, University of Chile Clinical Hospital, Clínica Las Condes, Santiago, Chile.
Internal Medicine Department, University of Chile Clinical Hospital, Clínica Las Condes, Santiago, Chile.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Surgery .
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2008 (English)In: Digestive Diseases and Sciences, ISSN 0163-2116, Vol. 53, no 7, 1917-1928 p.Article in journal (Refereed) Published
Abstract [en]

We investigated myeloid-dendritic cell (DC) marker and Toll-like receptor (TLR)-2 and 4 distributions in ileal samples from Crohn's disease (CD) patients (n = 14) and controls (n = 13). In controls, no TLR-2+ cells were observed, and higher numbers of TLR-4+ and DC-SIGN+ cells (P < 0.01) were detected in ileal samples when compared versus colonic tissues. In non-inflamed CD ileum, TLR-4+ and DC-SGN+ cells were depleted from superficial areas of the villus, and a significant CD1a+ cell infiltration (P < 0.01) was observed when compared to ileal controls and non-inflamed colonic CD samples. In inflamed CD ileum, DC-SIGN+, CD1a+, TLR-4+ and few TLR-4 +DC-SIGN+ cells were detected as well as CD83 depletion. No correlation between TLR-2 and DC markers was detected in CD samples. A unique distribution of myeloid-DC markers characterized the CD ileum. Also, the presence of significant amounts of ileal CD1a+ cells may provide a relevant DC-mediated mechanism for antigen recognition in the pathogenesis of CD. © 2007 Springer Science+Business Media, LLC.

Place, publisher, year, edition, pages
2008. Vol. 53, no 7, 1917-1928 p.
Keyword [en]
CD1a, Crohn's disease, Dendritic cells, Inflammation, Toll-like receptor
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-45878DOI: 10.1007/s10620-007-0105-xOAI: diva2:266774
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-10

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Salim, Sa´adSöderholm, Johan D
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Faculty of Health SciencesSurgery Department of Surgery in Östergötland
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