liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
IFCC guideline for sampling, measuring and reporting ionized magnesium in plasma
Natl Inst Nutr, Clin Chem Lab, Tunis, Tunisia.
Hartford Hosp, Dept Pathol, Hartford, CT 06115 USA.
Univ Newcastle Upon Tyne, Dept Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
Instrumentat Lab, Lexington, MA USA.
Show others and affiliations
2008 (English)In: Clinical Chemistry and Laboratory Medicine, ISSN 1434-6621, Vol. 46, no 1, 21-26 p.Article in journal (Refereed) Published
Abstract [en]

Analyzers with ion-selective electrodes (ISEs) for ionized magnesium (iMg) should yield comparable and unbiased results for iMg. This IFCC guideline on sampling, measuring and reporting iMg in plasma provides a prerequisite to achieve this goal [in this document, "plasma" refers to circulating plasma and the forms in which it is sampled, namely the plasma phase of anticoagulated whole blood (or "blood"), plasma separated from blood cells, or serum]. The guideline recommends measuring and reporting ionized magnesium as a substance concentration relative to the substance concentration of magnesium in primary aqueous calibrants with magnesium, sodium, and calcium chloride of physiological ionic strength. The recommended name is "the concentration of ionized magnesium in plasma". Based on this guideline, results will be approximately 3% higher than the true substance concentration and 4% lower than the true molality in plasma. Calcium ions interfere with all current magnesium ion-selective electrodes (Mg-ISEs), and thus it is necessary to determine both ions simultaneously in each sample and correct the result for Ca2+ interference. Binding of Mg in plasma is pH-dependent. Therefore, pH should be measured simultaneously with iMg to allow adjustment of the result to pH 7.4. The concentration of iMg in plasma may be physiologically and clinically more relevant than the concentration of total magnesium. Furthermore, blood-gas analyzers or instruments for point-of-care testing are able to measure plasma iMg using whole blood (with intact blood cells) as the sample, minimizing turnaround time compared to serum and plasma, which require removal of blood cells.

Place, publisher, year, edition, pages
2008. Vol. 46, no 1, 21-26 p.
Keyword [en]
erythrocyte effect, heparin, influence factors, interference, ionized calcium, ionized magnesium, ion-selective electrode, lipophilic anions, liquid junction potential, pH, protein, sampling, silicone, sodium
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-45912DOI: 10.1515/CCLM.2008.001OAI: diva2:266808
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-10

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Larsson, Lasse
By organisation
Faculty of Health SciencesClinical Chemistry
In the same journal
Clinical Chemistry and Laboratory Medicine
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 53 hits
ReferencesLink to record
Permanent link

Direct link