False-reactive microbiologic screening test results in Swedish blood donors - how big is the problem? A survey among blood centers and deferred donors
2007 (English)In: Transfusion, ISSN 0041-1132, Vol. 47, no 1, 80-89 p.Article in journal (Refereed) Published
BACKGROUND: Screening of blood donors for markers of transfusion-transmissible infectious agents leads to a varying number of false-reactive test results and sometimes thereby temporary or permanent deferral of donors and also to loss of collected units. STUDY DESIGN AND METHODS: Data on false-reactive screening test results in 2002 and 2003 were collected from 19 blood centers in Sweden. A questionnaire was sent to donors deferred because of false-reactive screening test results to investigate their perception of the information and their reaction to the deferral. RESULTS: Testing of 21,189 samples from new donors and 423,543 donations from regular and/or repeat donors produced 1,059 false-reactive test results, mostly from hepatitis C virus antibody testing, and 299 deferrals. Six different human immunodeficiency virus tests led to between 0.02 and 0.2 percent false-reactive results. The deferral rate varied considerably between different counties. Of 204 deferred donors contacted, 180 (88%) answered the questionnaire. More than 80 percent were worried about their test results and worry was more common among those who did not feel sufficiently informed. CONCLUSION: The results imply that there is a need for a more standardized approach to the screening of blood donors and donations with the aim of minimizing the number of false-reactive screening test results. They also emphasize the importance of appropriate information and support to deferred donors.
Place, publisher, year, edition, pages
2007. Vol. 47, no 1, 80-89 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-45978DOI: 10.1111/j.1537-2995.2007.01067.xOAI: oai:DiVA.org:liu-45978DiVA: diva2:266874