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Association of E1AF mRNA expression with tumor progression and matrilysin in human rectal cancer
Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China, Shanxi Cancer Hospital, Taiyuan, China.
Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.
Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.
Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.
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2007 (English)In: Oncology, ISSN 0030-2414, E-ISSN 1423-0232, Vol. 73, no 5-6, 384-388 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To examine E1AF mRNA expression and to determine whether it is correlated with tumor progression and matrilysin in human rectal cancer. Methods: Real-time RT-PCR was used to determine E1AF and matrilysin expression in 100 matched rectal cancers and normal tissues. Results: Among the 100 rectal cancers, 69 cases of E1AF mRNA overexpression were observed. E1AF mRNA overexpression correlated well with matrilysin. In carcinomas, E1AF mRNA overexpression correlated significantly with depth of invasion, lymph node metastasis, venous involvement and advanced pTNM stage. Conclusions: E1AF was correlated significantly with tumor progression of human rectal cancer and may be an important factor in rectal cancer progression. Copyright © 2008 S. Karger AG.

Place, publisher, year, edition, pages
2007. Vol. 73, no 5-6, 384-388 p.
Keyword [en]
E1AF, Matrilysin, Real-time RT-PCR, Rectal cancer
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-46000DOI: 10.1159/000136158OAI: oai:DiVA.org:liu-46000DiVA: diva2:266896
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-13

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Sun, Xiao-Feng

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