liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Cardiovascular risk and renal transplantation: Post hoc analyses of the Assessment of Lescol in Renal Transplantation (ALERT) study
Show others and affiliations
2005 (English)In: American Journal of Kidney Diseases, ISSN 0272-6386, Vol. 46, no 3, 529-536 p.Article in journal (Refereed) Published
Abstract [en]

Background Renal transplantation is associated with an increased risk for premature cardiovascular disease. We analyzed the data in the placebo arm of Assessment of Lescol in Renal Transplantation (ALERT) to improve our understanding of the relationship between cardiovascular risk factors and outcomes in this unique population. Methods: We performed Cox survival analysis for myocardial infarction, cardiac death, and noncardiac death in 1,052 patients recruited to the placebo arm of ALERT. These subjects were aged 30 to 75 years, had stable graft function at least 6 months after transplantation, had a serum total cholesterol level between 155 and 348 mg/dL (4 and 9 mmol/L), and were receiving cyclosporine-based immunosuppression. Results: The results confirm previous studies. In multivarlate analysis, preexisting coronary heart disease (hazard ratio [HR], 3.69, P < 0.001), total cholesterol level (HR, 1.55 per 50 mg/dL, P = 0.0045), and prior acute rejection (HR, 2.36, P = 0.0023) were independent risk factors. Conversely, independent risk factors for cardiac death were age (HR, 1.58 per decade, P = 0.0033), diabetes (HR, 3.35, P = 0.0002), ST-T changes on the ECG (HR, 3.17, P = 0.0004), and serum creatinine level (HR, 2.65 per milligram per deciliter, P < 0.0001). Conclusion: This analysis confirms that renal transplant recipients share risk factors for myocardial infarction and cardiac death with the general population. However, the pattern of risk factors and their relationship with outcomes is atypical, highlighting the unique nature of cardiovascular risk in transplant recipients.

Place, publisher, year, edition, pages
2005. Vol. 46, no 3, 529-536 p.
Keyword [en]
cardiovascular risk, renal disease, transplantation
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-46075DOI: 10.1053/j.ajkd.2005.05.014OAI: diva2:266971
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-12

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Olsson, Anders
By organisation
Faculty of Health SciencesInternal Medicine Department of Endocrinology and Gastroenterology UHL
In the same journal
American Journal of Kidney Diseases
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 7 hits
ReferencesLink to record
Permanent link

Direct link