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Factors of importance for weight loss in elderly patients with Parkinson's disease
Linköping University, Department of Neuroscience and Locomotion, Geriatrics. Linköping University, Department of Medicine and Care, Nursing Science. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Geriatric. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Geriatric. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Internal Medicine. Linköping University, Faculty of Health Sciences.
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2004 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 110, no 3, 180-187 p.Article in journal (Refereed) Published
Abstract [en]

Objective –  Weight loss is reported frequently in patients with Parkinson's disease (PD). The objective of this study was to find the underlying factors of this phenomenon.

Participants and methods –  Twenty-six l-dopa-treated patients with PD and 26 age- and sex-matched healthy controls were assessed twice within a 1-year interval. Body weight, body fat mass, resting energy expenditure, physical activity, energy intake, thyroid hormones and cognitive function were investigated.

Results –  Nineteen (73%) of the PD patients lost body weight, although energy intake and the time for rest increased. Weight loss was most marked in patients with more severe PD symptoms and in whom cognitive function had decreased. Multiple regression analyses showed that determinants for weight loss were female gender, age and low physical activity.

Conclusion –  Weight loss was common in PD patients, in spite of the increased energy intake and was most obvious in patients with increased PD symptoms and decreased cognitive function.

Place, publisher, year, edition, pages
2004. Vol. 110, no 3, 180-187 p.
Keyword [en]
Parkinson's disease, weight loss, body fat mass, energy expenditure, energy intake, thyroid hormones, physical activity, cognitive function
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-46206DOI: 10.1111/j.1600-0404.2004.00307.xOAI: oai:DiVA.org:liu-46206DiVA: diva2:267102
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-13Bibliographically approved
In thesis
1. Weight loss in elderly patients with Parkinson's disease
Open this publication in new window or tab >>Weight loss in elderly patients with Parkinson's disease
2005 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The aim of this thesis was to investigate possible factors concerning weight loss in elderly patients with untreated, as well as treated Parkinson's disease (PD) and to compare PD patients with age and sex matched controls. Twenty-eight PD patients (15 newly diagnosed and 13 previously treated) and 28 sex and age matched controls were included in the study.

Data on body weight, body fat mass, lean body mass, PD symptoms, cognitive function, dysphasia, oral and dental state, resting energy expenditure, food habits, olfactory ability and physical activities were collected prospectively, and all variables were assessed repeatedly three times with one year between investigations: Baseline, year 1 and year 2. The previously treated PD patients and their controls were assessed twice, at year 1 and year 2. After one year, when the de novo PD patients had been optimally treated with L-dopa, the two groups of PD patients were combined into one group for the purpose of analysis.

Twenty-six of the PD patients were able to participate to the end of the study, and the results were compared with those of their 26 controls. The PD patients had lower housework activity, a longer period of daily rest, fewer could do their own food shopping and cooking and more patients had impaired olfaction and presence of dysphagia, both at year 1 and at year 2. At year two, the PD patients also had lower body weight, body fat mass, lean body mass, physical activity and mobility. The PD patients had a higher number of eating events, compared with the controls at year one, but at year two the patients consumed fewer high quality snacks than their controls. There were no significant differences between PD patients and their controls with regard to daily intakes of energy, protein, fat and carbohydrates.

Nineteen of the PD patients lost body weight between year one and year two. In the weight losing patients, the PD symptoms, L-dopa dosage, and energy intake (kcal/kg body weight) increased as did their daily recumbent rest, while their cognitive function decreased. Multiple regression analysis showed that women with low cognitive function were predisposed to weight loss. The consumption of solid food decreased.

Conclusion: Weight loss was common in PD patients, in spite of increased energy intake. Food habits changed toward a lower number of adequate foods and their intake of solid food decreased. It has to be discussed whether weight loss in PD patients is part of this neurodegenerative process and L-dopa treatment could contribute to the weight loss.

Place, publisher, year, edition, pages
Linköping: Linköpings universitet, 2005. 46 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 896
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-33457 (URN)19478 (Local ID)91-85299-10-3 (ISBN)19478 (Archive number)19478 (OAI)
Public defence
2005-05-20, Berzeliussalen, Hälsouniversitetet, Linköping, 13:00 (Swedish)
Opponent
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2012-09-28Bibliographically approved

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Lorefält, BirgittaGanowiak, WojchiecPålhagen, SvenToss, GöranUnosson, MitraGranerus, Ann-Kathrine

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Lorefält, BirgittaGanowiak, WojchiecPålhagen, SvenToss, GöranUnosson, MitraGranerus, Ann-Kathrine
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