Elevated number of cells secreting transforming growth factor β in Guillain-Barré syndrome
2003 (English)In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 111, no 12, 1095-1104 p.Article in journal (Refereed) Published
We used ELISPOT and cell ELISA to study secretion of IL-4, IFN-γ, TGF-β, IL-6, and TNF-α by circulating mononuclear cells during the course of Guillain-Barré syndrome (GBS). Compared to healthy controls, patients with GBS had higher numbers of TGF-β-secreting cells and the number of individuals with myelin-peptide-induced IL-4 and TGF-β secretion was higher in the GBS group. No significant differences were seen concerning the predominantly pro-inflammatory cytokines IFN-γ, IL-6 or TNF-α. Our findings indicate a down-regulatory role for TGF-β and IL-4 in GBS.
Place, publisher, year, edition, pages
2003. Vol. 111, no 12, 1095-1104 p.
Cytokines, ELISPOT, Guillain-Barré, IL-4, Syndrome, TGF-ß
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-46369DOI: 10.1111/j.1600-0463.2003.apm1111204.xOAI: oai:DiVA.org:liu-46369DiVA: diva2:267265