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Cow-milk-free diet during last trimester of pregnancy does not influence diabetes-related autoantibodies in nondiabetic children
Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
2003 (English)In: IMMUNOLOGY OF DIABETES II: PATHOGENESIS FROM MOUSE TO MAN / [ed] Sanjeevi, CB; Eisenbarth, GS, New York Academy of Sciences, 2003, Vol. 1005, 275-278 p.Conference paper (Refereed)
Abstract [en]

The aim was to study whether cow-milk-free diet during the last trimester of pregnancy influences the development of diabetes-related autoantibodies in nondiabetic children. We also examined the effect of later introduction of cow milk proteins and gluten. Blood samples were taken from 205 children at 6 weeks, 6 months, 18 months, and 5 years, whose mothers had been randomized to either a cow-mllk-free diet or not during the last trimester of pregnancy. During the first 3 months of life, cow milk proteins were not fed to the children. Autoantibodies against GAD65 (GADA), tyrosine phosphatase (IA-2A), and insulin (IAA) were determined by a radioligand-binding assay. We found specific autoantibodles, although in low concentrations below the traditional cutoff for positivity in the children. The diet of the mother during pregnancy had no influence on development of autoantibodies, nor did duration of breast-feeding or time for introduction of gluten. Cow milk introduction between 3 and 6 months caused a transient increase in GADA at 6 months of age (p < 0.05). Children who developed atopic disease had significantly lower IA-2A at 6 months (p < 0.001).

Place, publisher, year, edition, pages
New York Academy of Sciences, 2003. Vol. 1005, 275-278 p.
, Annals of the New York Academy of Sciences, ISSN 0077-8923 ; 1005
Keyword [en]
Atopic disease, Autoantibodies, Cow milk, Pregnancy, Type 1 diabetes
National Category
Endocrinology and Diabetes
URN: urn:nbn:se:liu:diva-46407DOI: 10.1196/annals.1288.042ISI: 000187496100041ISBN: 1-57331-460-9OAI: diva2:267303
6th International Congress of the Immunology-of-Diabetes-Society and American-Diabetes-Association Research Symposium, Copper MT, Colorado, USA, October 3-6 2002
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2014-11-18Bibliographically approved

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Ludvigsson, Johnny
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PediatricsFaculty of Health SciencesDepartment of Paediatrics in Linköping
Endocrinology and Diabetes

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ReferencesLink to record
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