liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Vaccinations may induce diabetes-related autoantibodies in one-year-old children
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Pediatrics .
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Pediatrics . Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
2003 (English)In: Annals of the New York Academy of Sciences, ISSN 0077-8923, Vol. 1005, 404-408 p.Conference paper, Published paper (Other academic)
Abstract [en]

Vaccinations have been discussed as one among many environmental candidates contributing to the immune process that later may lead to type 1 diabetes. ABIS (All Babies in Southeast Sweden) is a prospective cohort study following a nonselected birth cohort of general population. In a randomly selected sample collection from 4400 children, GADA and IA-2A have been determined at the age of 1 year. The information on vaccinations was collected from questionnaires answered by the parents and was related to ß cell autoantibodies. When studying the induction of autoantibodies using the autoantibody level of 90th percentile as cutoff level, hemophdus influenza B (HIB) vaccination appeared to be a risk factor for IA-2A [OR 5.9 (CI 1.4-24.4, p = 0.01)] and for GADA [OR 3.4 (CI 1.1-10.8, p = 0.04)] in logistic regression analyses. Furthermore, the titers of IA-2A were significantly higher (p < 0.01 in Mann-Whitney test) in those children who had got HIB vaccination. When 99th percentile was used as cutoff to identify the children at risk of type 1 diabetes, BCG vaccination was associated with increased prevalence of IA-2A (p < 0.01). We conclude that HIB vaccination may have an unspecific stimulatory polyclonal effect increasing the production of GADA and IA-2A. This might be of importance under circumstances when the ß cell-related immune response is activated by other mechanisms.

Place, publisher, year, edition, pages
2003. Vol. 1005, 404-408 p.
Keyword [en]
ABIS, Autoantibodies, BCG vaccination, Children, Diabetes, HIB vaccination
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-46414DOI: 10.1196/annals.1288.068OAI: oai:DiVA.org:liu-46414DiVA: diva2:267310
Available from: 2009-10-11 Created: 2009-10-11

Open Access in DiVA

No full text

Other links

Publisher's full text

Authority records BETA

Vaarala, OutiLudvigsson, Johnny

Search in DiVA

By author/editor
Vaarala, OutiLudvigsson, Johnny
By organisation
Faculty of Health SciencesPediatrics Department of Paediatrics in Linköping
In the same journal
Annals of the New York Academy of Sciences
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 129 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf