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Can lipofuscin accumulation be prevented?
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Health Sciences.
2008 (English)In: Rejuvenation Research, ISSN 1549-1684, Vol. 11, no 2, 441-443 p.Article in journal (Refereed) Published
Abstract [en]

During normal autophagic degradation of mitochondria and iron-containing proteins in lysosomes, iron is released intralysosomally where it may react with hydrogen peroxide forming hydroxyl radicals (Fenton reaction). Depending on their rate of formation, these highly reactive radicals can cross-link intralysosomal material, leading to lipofuscin formation, or destabilize the lysosomal membrane, which induces apoptosis/necrosis. Since the sensitivity of lysosomes to oxidative stress can be manipulated by altering the intralysosomal level of redox-active iron, it follows that lipofuscin formation might also be influenced. It is suggested that pulse doses of iron chelators that easily penetrate membranes could be used to diminish lipofuscinogenesis. © 2008 Mary Ann Liebert, Inc.

Place, publisher, year, edition, pages
2008. Vol. 11, no 2, 441-443 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-46545DOI: 10.1089/rej.2007.0621OAI: diva2:267441
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2014-01-17Bibliographically approved

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