liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Multiplicity of eukaryotic ADH and other MDR forms
Jörnvall, H., Dept. of Med. Biochem./Biophysics, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Bioinformatics .
2003 (English)In: Chemico-Biological Interactions, ISSN 0009-2797, Vol. 143-144, 255-261 p.Conference paper (Other academic)
Abstract [en]

Eukaryotic genomes code for at least eight medium-chain dehydrogenases/reductases (MDR) enzyme families of two types, with and without Zn2+ at the active site. Four families have Zn2+: 'Dimeric alcohol dehydrogenases (ADHs)' (including liver ADHs), 'Tetrameric ADHs' (including the yeast ADHs), 'Cinnamyl ADHs' and 'Polyol DHs'. In the human genome, there are minimally 23 MDR genes, but the list is still growing from further interpretations. Of these, seven genes on chromosome 4 (and three pseudogenes) represent the ADH classes in the gene order IV, I?, Iß, Ia, V, II and III. The lineages leading to human ADH establish five levels of divergence, with nodes at the MDR/short-chain dehydrogenases/reductases (SDR), dimer/tetramer, class III/non-III, further class, and intraclass levels of divergence. These multiplicities allow conclusions on pathways of function for ADHs and suggest this activity to have two roles in addition to its function in metabolism, one of a basic defence nature, the other of regulatory value in higher eukaryotes. © 2002 Elsevier Science Ireland Ltd. All rights reserved.

Place, publisher, year, edition, pages
2003. Vol. 143-144, 255-261 p.
Keyword [en]
Alcohol dehydrogenase, Evolution, Evolutionary nodes, Functional roles, Human genome, Medium-chain dehydrogenases/reductases (MDR)
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-46569DOI: 10.1016/S0009-2797(02)00242-9OAI: diva2:267465
Available from: 2009-10-11 Created: 2009-10-11

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Persson, Bengt
By organisation
The Institute of TechnologyBioinformatics
In the same journal
Chemico-Biological Interactions
Engineering and Technology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 39 hits
ReferencesLink to record
Permanent link

Direct link