liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Coxsackievirus immunization delays onset of diabetes in non-obese diabetic mice
Enterovirus Laboratory, Natl. Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finland.
Härkönen, T., Enterovirus Laboratory, Natl. Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finland.
Enterovirus Laboratory, Natl. Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finland.
Enterovirus Laboratory, Natl. Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finland.
Show others and affiliations
2003 (English)In: Journal of Medical Virology, ISSN 0146-6615, E-ISSN 1096-9071, Vol. 69, no 4, 510-520 p.Article in journal (Refereed) Published
Abstract [en]

Enteroviruses may be involved in the pathogenesis of Type 1 diabetes through different mechanisms including triggering of autoimmunity. The effect of immunization with coxsackievirus B4-E2 on diabetes incidence was studied in the non-obese diabetic mice, an animal model for human autoimmune insulin-dependent diabetes mellitus. The immunization delayed the onset of diabetes in the mice, and the effect was mediated at least partially by virus immunization-activated splenocytes as demonstrated by adoptive transfer experiments. Immunization resulted in a strong humoral immune response against the immunizing virus, formalin-inactivated coxsackievirus B4-E2. Cell-mediated immune responseto virus antigen was characterised by interferon gamma and interleukin 10 secretion. The immunization also resulted in increased antibody levels against several beta-cell autoantigens. By using epitope mapping we were able to show that in addition to reactivity with the known epitopes of viral proteins and tyrosine phosphatase A-2 or heat shock protein 60, responses to some other regions of autoantigens were enhanced. In preproinsulin, the response was restricted against an antigenic region earlier identified as DR4-dependent epitope. This reactivity can not be explained by homologous amino acid sequences and it is possible that enterovirus immunization might change the autoantigen specific TH1/TH2 balance in non-obese diabetic mice. In conclusion, our results suggest that coxsackievirus immunization increased humoral immune response to beta cell autoantigens and this was associated with a less destructive pathology for spontaneous diabetes in non-obese diabetic mice. © 2003 Wiley-Liss, Inc.

Place, publisher, year, edition, pages
2003. Vol. 69, no 4, 510-520 p.
Keyword [en]
Antibodies, Beta-cell autoantigen, Coxsackievirus, Enterovirus, Immunization, Insulin-dependent diabetes mellitus, Non-obese diabetic mice, T-cell responses
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-46679DOI: 10.1002/jmv.10339OAI: oai:DiVA.org:liu-46679DiVA: diva2:267575
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-13

Open Access in DiVA

No full text

Other links

Publisher's full text

Authority records BETA

Vaarala, Outi

Search in DiVA

By author/editor
Vaarala, Outi
By organisation
Faculty of Health SciencesPediatrics
In the same journal
Journal of Medical Virology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 65 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf