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Integrated approaches to uncovering transcription regulatory networks in mammalian cells
Department of Bioengineering, Jacobs School of Engineering, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States.
Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Computational Biology .
Department of Bioengineering, Jacobs School of Engineering, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States, Scripps NeuroAIDS Preclinical Studies Center, Scripps Research Institute, La Jolla, CA 92037, United States.
2008 (English)In: Genomics, ISSN 0888-7543, Vol. 91, no 3, 219-231 p.Article, review/survey (Refereed) Published
Abstract [en]

Integrative systems biology has emerged as an exciting research approach in molecular biology and functional genomics that involves the integration of genomics, proteomics, and metabolomics datasets. These endeavors establish a systematic paradigm by which to interrogate, model, and iteratively refine our knowledge of the regulatory events within a cell. Here we review the latest technologies available to collect high-throughput measurements of a cellular state as well as the most successful methods for the integration and interrogation of these measurements. In particular we will focus on methods available to infer transcription regulatory networks in mammals.

Place, publisher, year, edition, pages
2008. Vol. 91, no 3, 219-231 p.
Keyword [en]
Bioinformatics, Cellular networks, ChIp-chip, Dynamics, Gene expression, Gene networks, Genomics, Networks, Personalized medicine, Protein interaction maps, Protein-protein interaction networks, Systems biology, Systems medicine, Transcriptional networks
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-46689DOI: 10.1016/j.ygeno.2007.11.005OAI: oai:DiVA.org:liu-46689DiVA: diva2:267585
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-10

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Tegnér, Jesper

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