liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Revisiting Salerno's sine-Gordon model of DNA: Active regions and robustness
Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology.
Linköping University, The Institute of Technology. Linköping University, Department of Science and Technology.ORCID iD: 0000-0003-0528-9782
2003 (English)In: Physica D: Non-linear phenomena, ISSN 0167-2789, Vol. 177, no 1-4, 233-241 p.Article in journal (Refereed) Published
Abstract [en]

We return to a simple model of DNA-transcription, first investigated by Salerno more than 10 years ago. One conjecture that time was that the promoter-regions were "dynamically active" in the sense that a stationary kink solution to the discrete sine-Gordon equation spontaneously starts to move when positioned in certain regions. Here we explore the whole genome of the bacteriophage T7, which is the same that was used in the first studies. We find that the regions in the promoters where the DNA-binding molecules attach have no special significance, while the start of the RNA-coding regions are dynamically active on a significant level. The results are checked to be robust by imposing an external disturbance in the form of a thermostat, simulating a constant temperature. © 2002 Elsevier Science B.V. All rights reserved.

Place, publisher, year, edition, pages
2003. Vol. 177, no 1-4, 233-241 p.
Keyword [en]
DNA, Genome-wide, Promoters, Robustness, Sine-Gordon
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-46698DOI: 10.1016/S0167-2789(02)00769-8OAI: diva2:267594
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2013-09-12

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Lennholm, ErikHörnquist, Michael
By organisation
The Institute of TechnologyDepartment of Physics, Chemistry and BiologyDepartment of Science and Technology
In the same journal
Physica D: Non-linear phenomena
Engineering and Technology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 250 hits
ReferencesLink to record
Permanent link

Direct link