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A validated decision model for treating the anaemia of myelodysplastic syndromes with erythropoietin + granulocyte colony-stimulating factor: Significant effects on quality of life
Hellström-Lindberg, E., Department of Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden, Department of Medicine, Karolinska Institute, Huddinge University Hospital, 141 86 Stockholm, Sweden.
Department of Haematology, Ullevål Hospital, Oslo, Norway.
Department of Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.
Depts. Med./Haematol. the Hospitals, Malmö, Sweden.
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2003 (English)In: British Journal of Haematology, ISSN 0007-1048, Vol. 120, no 6, 1037-1046 p.Article in journal (Refereed) Published
Abstract [en]

We have published previously a prototype of a decision model for anaemic patients with myelodysplastic syndromes (MDS), in which transfusion need and serum erythropoietin (S-Epo) were used to define three groups with different probabilities of erythroid response to treatment with granulocyte colony-stimulating factor (G-CSF) + Epo. S-Epo = 500 U/l and a transfusion need of < 2 units/month predicted a high probability of response to treatment, S-Epo > 500 U/l and =2 units/month for a poor response, whereas the presence of only one negative prognostic marker predicted an intermediate response. A total of 53 patients from a prospective study were included in our evaluation sample. Patients with good or intermediate probability of response were treated with G-CSF + Epo. The overall response rate was 42% with 28.3% achieving a complete and 13.2% a partial response to treatment. The response rates were 61% and 14% in the good and intermediate predictive groups respectively. The model retained a significant predictive value in the evaluation sample (P < 0.001). Median duration of response was 23 months. Scores for global health and quality of life (QOL) were significantly lower in MDS patients than in a reference population, and fatigue and dyspnoea was significantly more prominent. Global QOL improved in patients responding to treatment (P = 0.01). The validated decision model defined a subgroup of patients with a response rate of 61% (95% confidence interval 48-74%) to treatment with G-CSF + Epo. The majority of these patients have shown complete and durable responses.

Place, publisher, year, edition, pages
2003. Vol. 120, no 6, 1037-1046 p.
Keyword [en]
Anaemia, Erythropoietin, Granulocyte colony-stimulating factor, Myelodysplasia
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-46701DOI: 10.1046/j.1365-2141.2003.04153.xOAI: diva2:267597
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-13

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