Fibronectin, MMP-1 and histologic changes in rotator cuff disease
2002 (English)In: Journal of Orthopaedic Research, ISSN 0736-0266, Vol. 20, no 6, 1358-1364 p.Article in journal (Refereed) Published
This study was designed to investigate human surgical specimens from patients with impingement (n = 16), ruptured supraspinatus tendons (n = 7), frozen shoulder (n = 2) and controls (n = 9) with respect to histological changes and the presence of fibronectin and Matrix metalloprotease-1 (MMP-1). The biopsy of the middle part of the supraspinatus tendons was analyzed microscopically after staining with hematoxyline eosin, Van Giesons hematoxyline and Phospho Tungstic Acid Hematoxyline for visualization of fibrin. Immunofluorescent stainings for fibronectin and MMP-1 were performed. Histology and immunofluorescence were assessed blindly. Necrotic tendinous tissue and fibrin were found only in some specimens from ruptures. The staining for fibronectin was significantly increased among patients with a rupture. MMP-1 was, however, only infrequently found in specimens from patients with impingement and ruptures. Fibrosis and thinning of fascicles seemed to be a more non-specific finding, appearing in control, impingement and rupture specimens. In conclusion, necrotic tendinous tissue, fibrin and fibronectin appear to be signs of tendon degeneration, whereas fibrosis and thinning of fascicles were found also in controls. © 2002 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.
Place, publisher, year, edition, pages
2002. Vol. 20, no 6, 1358-1364 p.
Fibronectin, Impingement syndrome, Matrix metalloprotease-1 (MMP-1), Rotator cuff rupture
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-46791DOI: 10.1016/S0736-0266(02)00057-8OAI: oai:DiVA.org:liu-46791DiVA: diva2:267687