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Developments in laser Doppler blood perfusion monitoring
Department of Physics, University of Limerick, Limerick, Ireland.
De Mul, F.F.M., Department of Applied Physics, University of Twente, Enschede, Netherlands.
Department of Biomedical Engineering, University of Linkoping, Linkoping, Sweden.
Inst. of Biocybernet./Biomed. Eng., Warsaw, Poland.
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2002 (English)In: Proceedings of SPIE, the International Society for Optical Engineering, ISSN 0277-786X, Vol. 4876, no 1, 128-139 p.Conference paper (Other academic)
Abstract [en]

This paper reviews the development and use of laser Doppler perfusion monitors and imagers. Despite their great success and almost universal applicability in microcirculation research, they have had great difficulty in converting to widespread clinical application. The enormous interest in microvascular blood perfusion coupled with the 'ease of use' of the technique has led to 2000+ publications citing its use. However, useful results can only be achieved with an understanding of the basic principles of the instrumentation and its application in the various clinical disciplines. The basic technical background is explored and definitions of blood perfusion and laser Doppler perfusion are established. The calibration method is then described together with potential routes to standardisation. A guide to the limitations in application of the technique gives the user a clear indication of what can be achieved in new studies as well as possible inadequacy in some published investigations. Finally some clinical applications have found acceptability and these will be explored.

Place, publisher, year, edition, pages
2002. Vol. 4876, no 1, 128-139 p.
Keyword [en]
Biomedical Instrumentation, Blood Supply, Doppler Shift, Laser Doppler Flowmetry, Microcirculation
National Category
Natural Sciences
URN: urn:nbn:se:liu:diva-46847DOI: 10.1117/12.475841OAI: diva2:267743
Available from: 2009-10-11 Created: 2009-10-11

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