liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Acute myeloid leukemia with inv(16)(p13q22): Involvement of cervical lymph nodes and tonsils is common and may be a negative prognostic sign
Billström, R., Department of Hematology, Lund University Hospital, Lund, Sweden, Department of Hematology, University Hospital, SE-221 85 Lund, Sweden.
Department of Hematology, Malmö University Hospital, Malmö, Sweden.
Békássy, A.N., Department of Pediatrics, Lund University Hospital, Lund, Sweden.
Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Haematology.
Show others and affiliations
2002 (English)In: American Journal of Hematology, ISSN 0361-8609, E-ISSN 1096-8652, Vol. 71, no 1, 15-19 p.Article in journal (Refereed) Published
Abstract [en]

Acute myeloid leukemia (AML) with inv(16)(p13q22) or the variant t(16,16)(p13,q22), is strongly associated with the FAB subtype M4Eo. A high incidence of CNS involvement was reported in the 1980s, but otherwise little is known about the pattern of extamedullary leukemia (EML) manifestations in this AML type. We have compiled clinical and cytogenetic data on 27 consecutive AML cases with inv(16)/t(16,16) from southern Sweden. In general, these AMLs displayed the clinical features that have previously been described as characteristic for this disease entity: low median age, hyperleukocytosis, M4Eo morphology, and a favorable prognosis. However, CNS leukemia was only seen in relapse in one patient diagnosed in 1980, whereas the most common EML manifestation in our series was lymphadenopathy (5/27, 19%), most often cervical with or without gross tonsillar enlargement. A review of previously published, clinically informative cases corroborates that lymphadenopathy, with preference for the cervical region, is the most common EML at diagnosis in inv(16)-positive AML (58/175, 33%). CNS leukemia, on the other hand, has been reported in only 17% of the cases, mostly in the relapse setting, with a diminishing frequency over time, possibly due to protective effects of high-dose cytarabine. Other reported EML sites include the scalp, ovaries, and the intestine. Cervicotonsillar EML was in our series associated with a shorter duration of first remission, (P< 0.05), and may hence prove to be an important clinical parameter when deciding treatment strategies in AML with inv(16)/t(16,16). © 2002 Wiley-Liss, Inc.

Place, publisher, year, edition, pages
2002. Vol. 71, no 1, 15-19 p.
Keyword [en]
Acute myeloid leukemia, Extramedullary involvement, Inv(16), Lymphadenopathy, Prognosis
National Category
Natural Sciences
URN: urn:nbn:se:liu:diva-46914DOI: 10.1002/ajh.10170OAI: diva2:267810
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2012-01-07

Open Access in DiVA

No full text

Other links

Publisher's full text
By organisation
Department of Haematology
In the same journal
American Journal of Hematology
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 35 hits
ReferencesLink to record
Permanent link

Direct link