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Activation of the p38 MAP kinase pathway is required for foam cell formation from macrophages exposed to oxidized LDL
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Experimental Pathology .
Department of Immunology, Scripps Research Institute, 10550 North Torrey Pines Road, San Diego, CA, United States.
Department of Immunology, Scripps Research Institute, 10550 North Torrey Pines Road, San Diego, CA, United States.
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2002 (English)In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 110, no 6, 458-468 p.Article in journal (Refereed) Published
Abstract [en]

Endocytosis of oxidized low density lipoproteins (oxLDL) by macrophages, mediated by scavenger receptors, is thought to play a central role in foam cell formation and, thus, in the pathogenesis of atherosclerosis. OxLDL activates several MAP kinases, including the ERK, JNK and p38 MAP kinases, but the role of these activations in oxLDL uptake has not been studied. In the present investigation, we find that SB203580, a specific inhibitor of p38, blocks oxLDL-exposed J774 cells from becoming foam cells. Inhibition of foam cell formation by blockade of the p38 pathway is, at least in part, due to inhibition of oxLDL-induced up-regulation of the scavenger receptor CD36. Using pharmaceutical inhibitors and dominant active MAP kinase kinases, we demonstrated that activation of the p38 pathway, but not the ERK or JNK pathways, is necessary and sufficient to transactivate PPAR?, a nuclear receptor that has recently been shown to play a pivotal role in oxLDL-induced CD36 expression. Our results for the first time demonstrate a regulation of CD36 by p38, and the importance of the p38 pathway in regulation of foam cell formation.

Place, publisher, year, edition, pages
2002. Vol. 110, no 6, 458-468 p.
Keyword [en]
Foam cell, Oxidized LDL, P38 mitogen-activated protein kinase
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-46918DOI: 10.1034/j.1600-0463.2002.100604.xOAI: oai:DiVA.org:liu-46918DiVA: diva2:267814
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-13

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Zhao, MingLiu, YaweiBrunk, Ulf

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