liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Acute cholecystokinin effects on event-related potentials in healthy volunteers
Department of Psychiatry, University of Ottawa, Institute of Mental Health Research, Ottawa, Ont., Canada, Royal Ottawa Hospital, 1145 Carling Avenue, Ottawa, Ont. K1Z 7K4, Canada.
Royal Ottawa Hospital, Ottawa, Ont., Canada.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Psychiatry . Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Psychiatry.
Department of Psychiatry, University of Ottawa, Institute of Mental Health Research, Ottawa, Ont., Canada.
Show others and affiliations
2002 (English)In: Human Psychopharmacology: Clinical and Experimental, ISSN 0885-6222, Vol. 17, no 6, 285-291 p.Article in journal (Refereed) Published
Abstract [en]

This study investigated the effects of a continuous slow infusion of cholecystokinin tetrapeptide (CCK-4), a neuropeptide with panicogenic properties, on brain event-related potentials (ERPs) in healthy adults. Twenty-four volunteers, 15 females and 9 males, were assigned to infusion with either placebo or CCK-4 in a randomized, double-blind, parallel group design. ERPs, elicited within a standard auditory odd-ball paradigm requiring the counting of rare (20%) occurring 'deviant' tones interspersed among more frequent (80%) occurring 'standard' tones, were assessed once before infusion, and at 10 min and 40 min after the onset of infusion. Compared with the placebo, CCK-4 delayed the latencies of N100 and P200 components elicited by 'deviant' stimuli. No significant treatment differences were observed with respect to N200, P300b, mood or adverse symptoms. These preliminary findings suggest that CCK-4 may interfere with information processing relating to the selection of significant stimulating and as such, may be of relevance to mechanisms underlying panic disorder. Copyright © 2002 John Wiley & Sons, Ltd.

Place, publisher, year, edition, pages
2002. Vol. 17, no 6, 285-291 p.
Keyword [en]
CCK-4, Cholecystokinin, ERPs, Event-related potentials, Panic, Panic disorder
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-46926DOI: 10.1002/hup.417OAI: diva2:267822
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-13

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Gunnarsson, Tove
By organisation
Faculty of Health SciencesPsychiatry Department of Psychiatry
In the same journal
Human Psychopharmacology: Clinical and Experimental
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 42 hits
ReferencesLink to record
Permanent link

Direct link