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Is fibromyalgia a central pain state?
Linköping University, Department of Clinical and Experimental Medicine, Rehabilitation Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Medicine, Pain and Rehabilitation Centre.
2002 (English)In: Journal of Musculoskeletal Pain, ISSN 1058-2452, E-ISSN 1540-7012, Vol. 10, no 1-2, 45-57 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To review the literature concerning pain mechanisms in fibromyalgia [FMS]. Findings and Conclusions: Thirteen investigations using different methods, comprising 250 patients with FMS, confirm a biological dysfunction of the nociceptive system, especially in the central nervous system in the majority of patients with FMS. The hyperexcitability in the nociceptive nervous system may have different causes in the individual patient. Localized long-standing muscle pain, chronic stress, genetic factors, and hormonal changes may all play a role. Pain generators in the muscle may not be specific for FMS but may be of importance for initiating and maintaining pain and allodynia/hyperalgesia. © 2002 by The Haworth Press, Inc. All rights reserved.

Place, publisher, year, edition, pages
New York, USA: Informa Healthcare, 2002. Vol. 10, no 1-2, 45-57 p.
Keyword [en]
Central sensitization, Fibromyalgia, Muscular pain, Pain mechanisms
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-46947DOI: 10.1300/J094v10n01_05ISI: 000176557700006OAI: diva2:267843
5th World Congress on Myofascial Pain and Fibromyalgia (MYOPAIN 2001), Portland, OR, USA, September 9-13 2001
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2014-08-19Bibliographically approved

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Henriksson, Karl-Gösta
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