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Reduced intensity conditioning allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia: A retrospective study from the European Group for Blood and Marrow Transplantation
Service d'Hématologie Clinique, CHU Hôtel Dieu, Université de Nantes, Nantes, France, Service d'Hématologie Clinique, CHU Hôtel-Dieu, Université de Nantes, Place Alexis Ricordeau, F-44093 Nantes, France.
European Group for Blood and Marrow Transplantation (EBMT), Hopital Saint-Antoine, Université de Paris 6, Pierre et Marie Curie, Paris, France.
Centre Hospitalo-Universitaire de Bordeaux, Hôpital Haut-Leveque, Pessac, France.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Oncology . Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Haematology UHL.
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2008 (English)In: Haematologica, ISSN 0390-6078, E-ISSN 1592-8721, Vol. 93, no 2, 303-306 p.Article in journal (Refereed) Published
Abstract [en]

This retrospective study reported the outcome of 97 adult acute lymphoblastic leukemia patients who received a reduced-intensity conditioning allogeneic stem cell transplantation. With a median follow-up of 2.8 years, two year overall-survival, leukemia-free survival and non-relapse mortality were significantly better in patients transplanted in first complete remission (CR1, 52±9%, 42±10%, and 18±7% respectively) compared with those transplanted in more advanced phase (p=0.003, p=0.002 and p=0.01 respectively). In multivariate analysis, disease status (CR1 vs. advanced, p=0.001) and chronic graft-vs-host disease (p=0.01) were associated with an improved overall-survival, suggesting that reduced-intensity conditioning allogeneic stem cell transplantation is feasible in patients with high risk lymphoblastic leukemia in remission at transplantation. ©2008 Ferrata Storti Foundation.

Place, publisher, year, edition, pages
2008. Vol. 93, no 2, 303-306 p.
Keyword [en]
Acute lymphoblastic leukemia, Allogeneic SCT
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-46989DOI: 10.3324/haematol.11960OAI: oai:DiVA.org:liu-46989DiVA: diva2:267885
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-13

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Theorin, Niklas

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