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Gas sensor arrays for early detection of infection in mammalian cell culture
Cell Culture Production, Pharmacia AB, S-112 87 Stockholm, Sweden.
Cell Culture Production, Pharmacia AB, S-112 87 Stockholm, Sweden.
Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Biotechnology .
2002 (English)In: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 17, no 5, 395-403 p.Article in journal (Refereed) Published
Abstract [en]

The detection of bacterial infections in a mammalian cell culture process is realised using a gas sensor array. In production-scale and laboratory-scale cultivations of a perfused recombinant CHO-cell culture producing human blood coagulation Factor VIII, we show that the gas sensor array identifies bacterial contamination earlier than conventional methods. The sensitivity of the instrument is verified by inoculation of a blank cell culture medium with defined bacterial cell counts. © 2002 Elsevier Science B.V. All rights reserved.

Place, publisher, year, edition, pages
2002. Vol. 17, no 5, 395-403 p.
Keyword [en]
Bioprocess contamination, Gas sensor array, On-line monitoring
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-47059DOI: 10.1016/S0956-5663(01)00315-3OAI: oai:DiVA.org:liu-47059DiVA: diva2:267955
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-13

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Mandenius, Carl-Fredrik

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