Efficient routes to glucosamine-myo-inositol derivatives, key building blocks in the synthesis of glycosylphosphatidylinositol anchor substances
2002 (English)In: Tetrahedron, ISSN 0040-4020, Vol. 58, no 7, 1387-1398 p.Article in journal (Refereed) Published
Short synthetic routes to protected derivatives of 2-amino-2-deoxy-a-D-glucopyranosyl-(1?6)-D-myo-inositol are described. Various 2-azido-2-deoxy-glucosyl donors were synthesized, starting from D-glucal or glucosamine hydrochloride. Derivatives of 1,2- and 2,3- D-myo-inositol-camphanylidene acetals were prepared to function as glycosyl acceptors. The subsequent glycosylations produced useful building blocks for the synthesis of GPI-anchor substances. © 2002 Elsevier Science Ltd. All rights reserved.
Place, publisher, year, edition, pages
2002. Vol. 58, no 7, 1387-1398 p.
Anchoring system, Glucosamine-myo-inositol, Glycosylphosphatidylinositol
Engineering and Technology
IdentifiersURN: urn:nbn:se:liu:diva-47105DOI: 10.1016/S0040-4020(01)01241-8OAI: oai:DiVA.org:liu-47105DiVA: diva2:268001