Transdifferentiation of neoplastic cells
2001 (English)In: Medical Hypotheses, ISSN 0306-9877, Vol. 57, no 5, 655-666 p.Article in journal (Refereed) Published
Transdifferentiation is a process in which a stable cell's phenotype changes to that of a distinctly different cell type. It occurs during certain physiological processes and leads to transition of tumor cell phenotypes. The latter process includes neoplastic epithelial-epithelial transition, neoplastic epithelial-mesenchymal transition, neoplastic mesenchymal-epithelial transition and transition between non-neural and neural neoplastic cell. This phonomenon is exemplified in some origin-debated tumors, such as carcinosarcoma, pleomorphic adenoma, synovial sarcoma, Ewing's/pPNET, and malignant fibrohistiocytoma. We propose that differentiation disturbance of cancer cells should include not only undifferentiation and dedifferentiation, but also transdifferentiation as well. Tumor cell transdifferentiation may be influenced or determined by cellular genetic instabilities, proliferation and apoptosis, as well as by extracellular matrix and growth factors. © 2001 Harcourt Publishers Ltd.
Place, publisher, year, edition, pages
2001. Vol. 57, no 5, 655-666 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-47161DOI: 10.1054/mehy.2001.1435OAI: oai:DiVA.org:liu-47161DiVA: diva2:268057