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The frequency of anti-C + anti-G in the absence of anti-D in alloimmunized pregnancies
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Transfusion Medicine. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Immunology and Transfusion Medicine.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Pathology and Clinical Genetics.
2001 (English)In: Transfusion Medicine, ISSN 0958-7578, E-ISSN 1365-3148, Vol. 11, no 3, 207-210 p.Article in journal (Refereed) Published
Abstract [en]

Anti-D+C are often initially identified in sera from alloimmunized women. Anti-G may be present in these samples, mimicking anti-D+C, and therefore the differentiation of anti-D, -C and -G may be important. Sera from 27 alloimmunized women, initially identified as containing anti-D + anti-C, were analysed by adsorption/elution studies in the presence of polyethylene glycol (PEG) using R0r (D+C-G+) and r'r(D-C+G+) red blood cells (RBC). Additionally, 15/27 samples were tested by adsorption in the presence of PEG and subsequently warm elution, using rGr (D-C-G+) RBC. Anti-G + anti-C, without anti-D, were identified in 4/27 samples (14.8%) and none of the newborn children needed postpartum treatment. The combination of D+G, D+C and D+C+G antibodies occurred in 25.9%, 11.1% and 48.1% of the women, respectively. Overall, anti-G was detected in 24/27 samples (88.9%). Pregnant women shown to have anti-G+C but not anti-D should receive Rh immune globulin. Additionally, the finding of apparent anti-D+C during pregnancy in D-negative spouses may lead to paternity testing and therefore a correct antibody identification is necessary.

Place, publisher, year, edition, pages
2001. Vol. 11, no 3, 207-210 p.
Keyword [en]
Anti-G, Haemolytic disease of the newborn (HDN), Polyethylene glycol (PEG), Pregnancy, Rh(D) alloimmunization
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-47180DOI: 10.1046/j.1365-3148.2001.00306.xOAI: oai:DiVA.org:liu-47180DiVA: diva2:268076
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-13

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Palfi, MiodragGunnarsson, Cecilia

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Faculty of Health SciencesTransfusion MedicineDepartment of Clinical Immunology and Transfusion MedicineDepartment of Clinical and Experimental MedicineDepartment of Clinical Pathology and Clinical Genetics
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