Efficient synthesis of polylactosamine structures through regioselective glycosylations
2001 (English)In: Journal of carbohydrate chemistry, ISSN 0732-8303, Vol. 20, no 7-8, 569-583 p.Article in journal (Refereed) Published
Di-, tri-and tetramers of ß-(1?3)-linked N-acetyllactosamine residues have been synthesised as their methyl glycosides, to be used in ITC binding studies to various galectins. The synthetic strategy involves two types of regioselective glycosylations: couplings of a galactosyl donor to 3,4-diol N-tetrachlorophthalimido glucose acceptors to give the lactosamine monomer building blocks, and subsequent formation of the oligomers through consecutive couplings of lactosamine donors to 2',3',4'-lactosamine acceptors, with high selectivity for the desired products.
Place, publisher, year, edition, pages
2001. Vol. 20, no 7-8, 569-583 p.
Engineering and Technology
IdentifiersURN: urn:nbn:se:liu:diva-47189DOI: 10.1081/CAR-100108275OAI: oai:DiVA.org:liu-47189DiVA: diva2:268085