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Angiotensin converting enzyme gene polymorphism predicts blood pressure response to angiotensin II receptor type 1 antagonist treatment in hypertensive patients
Department of Internal Medicine, Uppsala University Hospital, Uppsala, Sweden, Department of Internal Medicine, Uppsala University Hospital, SE-751 85, Uppsala, Sweden.
Department of Internal Medicine, Uppsala University Hospital, Uppsala, Sweden.
Department of Internal Medicine, Uppsala University Hospital, Uppsala, Sweden.
Division of Internal Medicine, Karolinska Institute, Danderyd Hospital.
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2001 (English)In: Journal of Hypertension, ISSN 0263-6352, Vol. 19, no 10, 1783-1787 p.Article in journal (Refereed) Published
Abstract [en]

Objectives To determine whether polymorphisms in the renin-angiotensin system can predict blood pressure-lowering response to antihypertensive treatment, more specifically, in response to treatment with irbesartan or atenolol. Design and methods Eighty-six patients with hypertension were randomized to double-blind treatment with either the angiotensin II type 1 receptor antagonist irbesartan or the ß1 adrenergic receptor blocker atenolol and followed for 3 months. We analysed angiotensinogen T174M and M235T, angiotensin converting enzyme (ACE) I/D and angiotensin II type 1 receptor A1166C polymorphisms and related them to blood pressure reduction. Results The mean reductions in blood pressure were similar for both treatments. In the irbesartan group, individuals homozygous for the ACE gene I allele showed a greater reduction in diastolic blood pressure, exceeding those with the D allele (-18±11 SD versus -7±10 mmHg, P=0.0096). This was not the case during treatment with atenolol, and the interaction term between type of treatment and ACE II genotype was significant (P=0.0176). The angiotensinogen and angiotensin II type 1 receptor polymorhisms were not related to the response to treatment Conclusions ACE genotyping predicted the blood pressure-lowering response to antihypertensive treatment with irbesartan but not atenolol. Thus, specific genotypes might predict the response to specific antihypertensive treatment. © 2001 Lippincott Williams & Wilkins.

Place, publisher, year, edition, pages
2001. Vol. 19, no 10, 1783-1787 p.
Keyword [en]
Genes, Pharmacology, Renin-angiotensin system, Treatment
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-47245DOI: 10.1097/00004872-200110000-00012OAI: oai:DiVA.org:liu-47245DiVA: diva2:268141
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2013-09-10

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Nyström, Fredrik

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Faculty of Health SciencesInternal Medicine Department of Endocrinology and Gastroenterology UHL
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